Epub 2017 Mar 30. In the digestive tract, elastase is not broken down by other enzymes and is eventually eliminated from the body in the stool. He said range is above >200. Pancreatic insufficiency in cystic fibrosis. doi: 10.1152/ajpgi.00060.2017. Practical guide to exocrine pancreatic insufficiency Breaking the myths. Floating, smelly, greasy stools for months. . Clin Exp Gastroenterol. Those with PEI must take PERT with each meal or snack that contains fat and/or protein. Also Known As: Elastase, stool, Pancreatic Elastase, Fecal Pancreatic Elastase, Human Fecal Elastase-1, FE-1. Results. After a wash step, a peroxidase-labeled conjugate (mouse anti-pancreatic elastase) is added. Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment. Hi Sparkle44- A high fecal elastase test is a strong indicator of exocrine pancreatic insufficiency (EPI) meaning your pancreas isnt producing enough enzymes to digest and absorb food properly. In-depth research on any test at your fingertips, all stored and tracked in one place. 24 No 1: 117-123. When you consume PERT with food, it duplicates the normal digestive process because the enzymes mix with the food and help you absorb more nutrition from the food and supplements that you consume. I am so glad you got in touch though as this is very timely on Wednesday I have been asked to have a 24 test to monitor reflux which involves having a tube inserted into my nose and into my gut I might chicken out!! Advertising on our site helps support our mission. People with EPI have a particularly difficult time absorbing fats from foods. Contribute to chinapedia/wikipedia.en development by creating an account on GitHub. Upload your lab report and well interpret and provide you with recomendations today. Malluta F, Maluf-Filho F, Leite AZA, Ortiz-Agostinho CL, Nishitokukado I, Andrade AR, Lordello MLL, Santos FMD, Sipahi AM. Available online at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848141/. To view profiles and participate in discussions please. If specimen cannot be sent immediately, freeze specimen and send frozen. It is a key part of your digestive process. 2. We've put industry-leading security standards in place to help protect against the loss, misuse, or alteration of the information under our control. HHS Vulnerability Disclosure, Help Dig Dis Sci. PMC Hope this helps. GitHub export from English Wikipedia. The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. The aim of this study was to evaluate this assay in subjects including patients with SCP with steatorrhea, patients with MCP with no steatorrhea, healthy controls, and diseased controls with nonpancreatic malabsorption. The intraassay and interassay intraclass correlation coefficients were 0.93 and 0.90, respectively. al. The sample should be formed (not watery) and not contaminated with urine or water. Accessed on 3/19/17. Whitcomb, D. ( 2009). al. Lower levels may indicate pancreatic insufficiency or other problems with fat digestion. A stool sample is collected in a clean container. An alternate to the 72-hour fecal fat test is the measurement of PE in stool. Optimal Result: (2016 February 21). It is a key part of your digestive process. Fecal elastase test (FE-1): This test is done to look for an enzyme called elastase that is released from the pancreas during digestion. Generally, a level of at least 200 micrograms per gram (mcg/g) is considered normal. Clinical Chemistry 51, No. Should i test pancreatic elastase,alfa antitripsin, calprotectin if i have gerd?are the symptoms of bloating because of gerd or low acidity in stomach. Faecal elastase 1: not helpful in diagnosing chronic pancreatitis associated with mild to moderate exocrine pancreatic insufficiency. My result came back with a flag next to it. Pancreatic Elastase-1 - The Elastase-1 is a quantitative enzyme linked immunosorbent assay for measuring concentrations of elastase-1 in feces as an aid in diagnosis of the exocrine pancreatic function. Exocrine Pancreatic Insufficiency (EPI). Diagnosis and treatment of pancreatic exocrine insufficiency. ARUP Consult. These results may differ from previously described data because of the purposeful inclusion of MCP subjects, documented by the lack of steatorrhea, and the inclusion of disease controls with nonpancreatic malabsorption. 2018 Aug;16(8):1220-1228.e4. 2013 Nov 14; 19(42): 72587266. Chronic Pancreatitis. However, there are options available that make it easier for the body to break down and absorb nutrients, which can help reduce the steatorrhea and nutritional deficiencies that PEI causes. Ensure you stay hydrated, but dont drink with meals (it dilutes those important digestive juices). Accessed on 3/19/17. 200 - 1000 mcg/g. The pancreatic elastase 1 fecal test is used to diagnose insufficiencies of the pancreas that result in diseases such as: In many of these conditions, there is often diarrhea, weight loss, undigested food in the stool, and pain in the abdomen. Are Your Adrenals Sabotaging Your Health? Worthington Cat#: LS004196) and pancreatic porcine elastase (500 mg/pig, Sigma Chemical Co, Cat#: 400-146P) were made in the infra-renal segment of the aorta in all animals. To help detect and evaluate pancreatic insufficiency, When you have signs and symptoms such as stomach cramps, weight loss, malnutrition, malabsorption, delayed growth (in children) and fatty, foul-smelling stools and pancreatic insufficiency is suspected, A fresh formed stool sample that is not contaminated with urine. Whats to Know About Exocrine Pancreatic Insufficiency? Diagnostic Performance of Measurement of Fecal Elastase-1 in Detection of Exocrine Pancreatic Insufficiency: Systematic Review and Meta-analysis. There are minimal risks associated with a pancreatic elastase . 2023 TESTING.COM. Right Side Abdominal Pain Symptoms, Causes, Diagnosis, Treatment, Left Side Abdominal Pain Symptoms, Causes, Diagnosis, Treatment. We will discuss the evidence that determination of the faecal concentration of pancreatic elastase 1 with an enzyme-linked immunosorbent assay method fulfils these criteria and thus provides an ideal tool to assess . Available online at https://emedicine.medscape.com/article/2121028-overview Accessed on 3/19/17. Pancreatic Insufficiency. All SCP had values of < 100 micrograms/g but more than half of the MCP subjects had FPE1 levels within the normal range. 1995-2023 Mayo Foundation for Medical Education and Research. 10 year old daughter failure to thrive on high caloric diet 136 pancreatic elastase sweat test negative what else could be wrong to cause this? This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. To learn more, please visit our. The level in the stool is decreased when the exocrine tissues of the pancreas are not producing sufficient elastase and other digestive enzymes. The enzyme stability is remarkably high despite its proteolytic activity, as elastase is found in feces in about a sixfold concentration as in pancreatic fluid. i have crohn's. An acidic stop solution is added causing the color to change from blue to yellow. American Pancreatic Association Practice Guidelines in Chronic Pancreatitis: evidence-based report on diagnostic guidelines. Plus, my Homocysteine is 3 times higher than it should be and my TSH is now under-active and I am on Thyroid tablets. Controversy: Is Coffee Bad For Your Thyroid? Treatment for EPI centers on administration of pancreatic enzyme replacement therapy. Pancreatic elastase (PE) is not degraded during intestinal transit and the concentration of PE in a stool sample reflects exocrine pancreatic function. Hashimotos Success Stories and Gratitude for Healing in 2022, Thyroid-Friendly Recipes for Thanksgiving, The Ultimate Guide To Using Enzymes with Hashimotos, How Myo-inositol Can Improve Hashimotos Symptoms, Approach to Fibrocystic Breasts with Hashimotos, The role of the pancreas and pancreatic elastase, How Hashimotos affects pancreatic enzyme deficiency, Symptoms and testing for pancreatic enzyme deficiencies, Giardia (and potentially other parasitic) infections, Indigestion/fullness 2-4 hours after a meal, Bloating or flatulence 2-4 hours after a meal, Diarrhea, or oil/grease present during bowel movements, Gallbladder pain (right side, under ribs), gallstones, or gallbladder removal, Low vitamin levels (A, D, E, and K) even after supplementing (I see this very often, as the body is not able to absorb and utilize the vitamins in such supplements), Dry, itchy, scaly, or flaky skin, rashes or eczema, Chicken skin (tiny bumps on the back of arms), Immune system imbalance (getting sick more often), Numbness and tingling (peripheral neuropathy). Common tests that your healthcare provider may perform to determine EPI include: 3. Hi Linda thanks so much for your response. Formal Name: Fecal Elastase-1. Follow your healthcare providers recommendations for taking PERT, and be sure to take it with every meal or snack. Save time on interpreting lab results with the largest database of biomarkers online. Secretin pancreatic function test to test how the pancreas responds to secretin, a hormone that triggers the release of digestive enzymes. (2001 October). Techniques, Purpose, Procedure, 5 Simple Ways To Increase HDL Cholesterol Levels. Epub 2018 Jan 31. Elastase helps break down fats, proteins, and carbohydrates after you eat. 2017;23(39):7059-76. (2015 March). standardrange200? The latter three tests were performed on three stool samples collected over 24 . Abstract. Which test is better for diagnosing pancreas insufficiency: stool panc elastase or serum lipase/amylase? , Hiya this is beautifully reassuring thanks so much for sharing x. Hiya Linda thanks so much you are a gem! They may find symptom relief and nutritional improvement from prescribed enzymes taken by mouth (oral) and vitamin supplements. However, it is most important to work with your healthcare team to treat the underlying cause of PEI. Less common etiologies of exocrine pancreatic insufficiency. If little or none is found, it can be a sign of EPI. what could cause this? They have also diagnosed me with a mild bile malabsorption issue. Little (or no) elastase can indicate EPI. If not ordering electronically, complete, print, and send 1 of the following forms with the specimen: -Gastroenterology and Hepatology Client Test Request. Protease and elastase, which break down proteins. Available online at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735004/. They may be able to stop PERT. The information on healthmatters.io is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. My result is 800+ ug/g This is above the normal range. Because cystic fibrosis and SDS are inherited, you cant prevent them or lower the risk of EPI with the conditions. It is generally diagnosed if faecal elastase-1 (FE-1) levels are below 200 g/g. Struyvenberg, M. et. He is a specialist at Cedars Sinai in LA and does extensive research/treatment of the pancreas. Underweight individuals will need to focus on high-calorie foods, to get enough energy for optimal health. Duggan, S. et. Waldum HL, Kleveland PM, Srdal F. All those with SDS have some degree of pancreatic insufficiency beginning in infancy. Many people with Hashimotos have the opposite issue , Consider adding digestive herbs to the meal (note that. If you are diagnosed with chronic pancreatitis, there are treatments that can help manage your condition. 2016 Feb 21; 22(7): 23042313. 200 - 1000 mcg/g. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, https://gastro.org/practice-guidance/gi-patient-center/topic/exocrine-pancreatic-insufficiency-epi/, (https://gastro.org/practice-guidance/gi-patient-center/topic/exocrine-pancreatic-insufficiency-epi/), https://staywell.mydigitalpublication.com/publication/?m=61769&i=632012&p=1, (https://staywell.mydigitalpublication.com/publication/?m=61769&i=632012&p=1), https://labtestsonline.org/conditions/pancreatic-insufficiency, (https://labtestsonline.org/conditions/pancreatic-insufficiency), https://www.merckmanuals.com/home/digestive-disorders/malabsorption/overview-of-malabsorption, (https://www.merckmanuals.com/home/digestive-disorders/malabsorption/overview-of-malabsorption), (https://shwachman-diamond.org/about-sds/), https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656454/, (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656454/), https://www.cysticfibrosisjournal.com/article/S1569-1993(17)30813-5/fulltext, (https://www.cysticfibrosisjournal.com/article/S1569-1993(17%2930813-5/fulltext), https://pancreasfoundation.org/patient-information/ailments-pancreas/exocrine-pancreatic-insufficiency-epi/, (https://pancreasfoundation.org/patient-information/ailments-pancreas/exocrine-pancreatic-insufficiency-epi/), Visitation, mask requirements and COVID-19 information. In-depth research on any test at your fingertips, all stored and tracked in one place. FOIA Treatments focus on getting your body the nutrients it needs to maintain good health. (2013 November 14 Updated). Last reviewed by a Cleveland Clinic medical professional on 06/10/2021. This depends on the laboratory performing the testing. National Library of Medicine Separate specimens must be submitted when multiple tests are ordered. Accessed on 3/19/17. The sample is then sent to a laboratory, where it is analyzed to determine the level of elastase present. From there, we can identify if it's at the appropriate level to be able to digest food and maintain adequate pancreas function.". Lipski L. Remove, Replace and Replenish: The Diet Prescription and Supplementation Part 2. Interpret your laboratory results instantly with us. Elastase helps break down fats, proteins, and carbohydrates after eating. Singh VK, Haupt ME, et al. (The active ingredient is ox bile, which has been shown to increase bile flow and support fat digestibility in animal studies. Pancreatic elastase present in the patient samples is determined directly from this curve. This leads to uncomfortable digestive problems, such as: Many digestive problems cause symptoms similar to EPI. It is not diagnostic, but it does indicate that further testing may be indicated. We do not endorse non-Cleveland Clinic products or services. GI Effects Stool Profile | Genova Diagnostics, https://www.labcorp.com/test-menu/32666/pancreatic-elastase-fecal, https://www.gdx.net/product/pancreatic-elastase-test-stool, https://www.childrensmn.org/references/lab/urinestool/pancreatic-elastase-stool.pdf, Navigate to GI Effects Stool Profile | Genova Diagnostics. Careers. Available online at https://www.ncbi.nlm.nih.gov/pubmed/11589385. 2019 Nov 15;12(1):67-73. doi: 10.1136/flgastro-2018-101171. 2017 Jul;62(7):1702-1712. doi: 10.1007/s10620-017-4602-2. United European Gastroenterol J. We use procedural, physical, and electronic security methods designed to prevent unauthorized people from getting access to this information. The most effective treatment for PEI is pancreatic enzyme replacement therapy (PERT), which involves taking a medication called pancrelipase to provide the body with enzymes that break down fats and proteins. Consider pepsin, plant or pancreatic enzyme supplements, digestive herbs, bile salts, and taurine. Clinics (Sao Paulo). Children inherit cystic fibrosis from a parent. Pancreatic elastase concentrations from 100-200 mcg/g are suggestive for moderate exocrine pancreatic insufficiency. Accessed on 3/19/17. This website uses cookies to ensure you get the best experience on our website. Our technology helps to understand, combine, track, organize, and act on your medical lab test results. 2017; 15: 29. This problem is called malabsorption. Yes pancreatic enzymes can affect stool testing results. The different types of pancreatic enzymes include: Chronic pancreatitis is the main cause of EPI in adults. My gastro specialist said that was great. Synopsis of recent guidelines on pancreatic exocrine insufficiency. https://www.medicalnewstoday.com/articles/310292.php Updated July 23, 2018. Pancreatic elastase concentrations above 200 mcg/g are normal and are not indicative of exocrine pancreatic insufficiency. (The active ingredient is milk thistle, a plant that contains, Increasing bile to better support fat digestion. Hiya HealthSleuths, I didnt find anything & just totally lost sight of this in amongst all the other health issues at the time. Digestive enzymes break down food, allowing your body to get nutrients. Its purpose is to help digest food, specifically proteins. Fecal pancreatic elastase is a non-invasive marker of exocrine pancreatic function. The normal range for stool elastase levels varies depending on the specific method used to measure the enzyme. It causes thick mucus to build up in the lungs, making breathing difficult. The .gov means its official. Guandalini, S. (2016 September 26 Updated). Pancreatic Elastase is an enzyme produced by exocrine tissue in the pancreas. There are minimal risks associated with a pancreatic elastase stool test. Nat Rev Gastroenterol Hepatol. Accessed June 22, 2019. Upload your lab reports and get interpretation today. PE has an important role in digestion, and proteolytically degrades proteins preferentially at alanine residues. Hi just wondering if anyone knows the relevance of a high fecal elastase test? Bansal, R. (2017 February Revised). It consists of two tightly connected glands, each with a distinct function. Elastase is one of them that's really important because it doesn't get degraded by bacteria, which means we can test it easily in stool," Dr. Hopson says. Does anyone know what can cause such an elevation? You'll give your doctor a solid stool sample. A Guide to Gallstones During Pregnancy. This group continues to be the most difficult group to diagnose clinically. The procedure for an elastase stool test involves collecting a small sample of stool in a special container. Micronutrient evaluation recommended, especially for fat soluble vitamins A, D, E, and K. Understand and improve your laboratory results with our health dashboard. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. And while fibre is good for gut health, for many individuals with PEI it is better to keep fibre intake low, as this can make digestion easier. However, the diagnostic accuracy of this test, an ELISA, is not clear. 1996;20(5):424-9. For the test, you receive secretin through an intravenous (IV) line. Pancreatic insufficiency can be caused by regular bouts of acute pancreatitis or by chronic pancreatitis. Did you ever turn up anything on high elastase? The National Pancreas Foundation. Dr Z 2011 May 31;8(7):405-415, 2. Abnormal Reports, SI Normal Reports | That might explain why my Folic Acid; Ferritin; Phosphate are all below the normal range. 2014 Nov;43(8):1143-62. doi: 10.1097/MPA.0000000000000237. Medical News Today. If you have PEI, it is a good idea to consult with a registered dietitian, who can work with you to establish a meal plan tailored to your lifestyle, that maximizes the nutritional quality of what you eat, and reverses any nutritional deficiencies. Accessed on 3/19/17. Had ulq pains 7months. The rest are at risk for developing EPI during childhood or adulthood. A doctor will usually order a lipase test if a person shows signs of a pancreatic disorder. *Normal exocrine pancreatic sufficiency: 200 to >500 ug E1/g stool *Moderate to mild exocrine pancreatic insufficiency: 100 - 200 ug E1/g stool *Severe exocrine pancreatic insufficiency: below 100 ug. Cystic fibrosis is the top cause of EPI in infants and children. Doctors find that the following conditions are associated with low levels of pancreatic elastase I: If used routinely in gastrointestinal practice, an abnormal result will frequently occur but this cannot be assumed to mean that the person has PEI. Are Flame Retardant Toxins Contributing to Your Thyroid Condition? Elastase is an enzyme produced by the pancreas that helps digest fats. Please enable it to take advantage of the complete set of features! In the aortic dilation control group, a 1 cm 4 cm media-soaked piece of Gelfoam was placed on . Thirty-six subjects [15 healthy controls, 7 malabsorption controls, and 14 subjects with CP (7 MCP, 7 SCP)] had FPE1 assays. Get useful, helpful and relevant health + wellness information. A ONECARE MEDIA COMPANY. 3 Pancreas.org. MeSH Clin Gastroenterol Hepatol. The majority of those with nonpancreatic malabsorption had false-positive values. Doctors typically provide answers within 24 hours. It is easier for your small intestine to absorb nutrients when there isnt as much food to digest at once. Consistency of raw fecal sample may affect analytical performance. People with pancreatic dysfunction often need to be monitored closely by their healthcare practitioner. EPI occurs when your pancreas doesnt make enough digestive enzymes. Mine is also above the lab ref range, >750. Top answers from doctors based on your search: Created for people with ongoing healthcare needs but benefits everyone. In the digestive tract, elastase is not broken down by other enzymes and . Elastase is an enzyme produced by special (exocrine) tissue in the pancreas. If your signs and symptoms continue and a strong suspicion of pancreatic insufficiency remains, your healthcare practitioner may order stool tests for fecal fat and chymotrypsin or blood tests for amylase and lipase to look at other aspects of pancreas and digestive function. American Gastroenterological Association. al. I would think that excludes pancreas problems. Lankisch PG, Schmidt I, Knig H, Lehnick D, Knollmann R, Lhr M, Liebe S. Gut. Early diagnosis is important as treatment with PERT alleviates symptoms, improves quality of life and helps prevent long-term complications related to fat malabsorption. Lower levels may indicate pancreatic insufficiency or other problems with fat digestion. Not all laboratories offer this test and your sample may need to be sent to a reference laboratory for testing. Hi Sparkle. 1998 Apr;42(4):551-4. doi: 10.1136/gut.42.4.551. SI Abnormal Reports. How Do Adaptogenic Herbs Benefit Hashimotos? Enzymes are proteins that cause chemical reactions in your body. This assay allows the diagnosis or exclusion of pancreatic exocrine insufficiency, which can be caused by chronic pancreatitis, cystic fibrosis, pancreatic tumor, cholelithiasis or . is this normally associated? The pancreas is part of your digestive system. Available online at https://pancreas.org/patients/testing-procedures/functional/. Optimal Result: Many tests are available to assess pancreatic function. Elastase (Pancreatic Elastase 1), S. 14048-3. Clin Chem Lab Med. All data is backed up multiple times a day and encrypted using SSL certificates. Clinical use Pancreatic elastase 1 or faecal elastase 1 (FE-1) is a human pancreas specific enzyme. Accessed on 3/19/17. People with EPI cant absorb enough fats, proteins and carbohydrates from foods. For these, please consult a doctor (virtually or in person). are my intestines functioning normally then? Exocrine pancreatic insufficiency in adults: A shared position statement of the Italian association for the study of the pancreas. If you have any concerns about the test, be sure to discuss them with your healthcare provider. 1999 Jan;44(1):210-3. doi: 10.1023/a:1026691209094. J Gastrointestin Liver Dis, March 2015 Vol. Fecal pancreatic elastase is a non-invasive marker of exocrine pancreatic function. Pancreatic Elastase, Feces Useful For Diagnosis of exocrine pancreatic insufficiency in case of unexplained diarrhea, constipation, steatorrhea, flatulence, weight loss, upper abdominal pain, and food intolerances Monitoring of exocrine pancreatic function in cystic fibrosis, diabetes mellitus, or chronic pancreatitis Method Name Capurso G, Traini M, Piciucchi M, Signoretti M, Arcidiacono PG: Exocrine pancreatic insufficiency: prevalence, diagnosis, and management. The polyclonal antibodies used in this assay are specifically directed against defined sequences of the human pancreatic elastase molecule. Policy. [L]. Levy, P. et. If specimen is sent refrigerate, send immediately after collection. Stay up to date with the latest news and information from Testing.com by subscribing to our newsletter. United European Gastroenterol J. It makes enzymes that aid digestion and help your body absorb nutrients. Elastase can be detected and measured in the stool when a persons pancreas is functioning normally. In a healthy pancreas, elastase will be eliminated in the stool. 2019 May 30;74:e853. EPI is most commonly caused by chronic pancreatitis but can also be associated with pancreatic cancer, pancreatic surgery, necrotizing acute pancreatitis, cystic fibrosis, inflammatory bowel disease (both Crohn disease and ulcerative colitis), diabetes (types I and II), gastric surgery, short bowel syndrome, and Zollinger-Ellison syndrome. I had a stool test that included pancreatic elastase 1 test, it came back low at 102 vs 201 mcg/g normal. About half of kids with SDS start producing digestive enzymes as they get older. The Elastase I protein is found concentrated in the stool, five times higher than what is found in pancreatic juice. Test Includes: Pancreatic stool elastase concentration measured in mcg/g stool. sharing sensitive information, make sure youre on a federal Please note, we cannot prescribe controlled substances, diet pills, antipsychotics, or other abusable medications. Most people will always need to use PERT to manage EPI symptoms. If present, pancreatic elastase will bind to the antibodies on the surface of the microtiter wells. There are no problems recorded in medical literature for high levels of Pancreatic Elastase I. Upload your lab report and well interpret and provide you with recomendations today. When the pancreas is damaged, these digestive enzymes can be found in the blood at higher levels than normal. Acetate, Akkermansia muciniphila, Anaerotruncus colihominis, Ancylostoma/Necator (Hookworm), Ascaris lumbricoides, Bacteroides vulgatus, Bacteroides-Prevotella group, Barnesiella spp., Beta-glucuronidase, Bifidobacterium longum, Bifidobacterium spp., Butyrivibrio crossotus, Calprotectin, Candida albicans/dubliniensis, Capillaria philippinensis, Cholesterol, Citrobacter species, Clostridium spp., Collinsella aerofaciens, Coprococcus eutactus, Desulfovibrio piger, Enterobacter cloacae, Enterobius vermicularis, Enterococcus faecalis, Eosinophil Protein X, Escherichia coli, Faecalibacterium prausnitzii, Fecal Color, Fecal Consistency, Fecal Fat, Total, Fecal Occult Blood, Fecal secretory IgA, Firmicutes/Bacteroidetes (F/B Ratio), Fusobacterium spp., Klebsiella oxytoca, Klebsiella species, Lactobacillus spp., Long-Chain Fatty Acids, Methanobrevibacter smithii, n-Butyrate %, n-Butyrate Concentration, Odoribacter spp., Oxalobacter formigenes, Pancreatic Elastase 1, Phospholipids, Prevotella spp., Products of Protein Breakdown (Total), Propionate, Proteus mirabilis, Pseudoflavonifractor spp., Roseburia spp., Ruminococcus spp., Short-Chain Fatty Acids (SCFA), Total, Triglycerides, Veillonella spp., Zonulin Family Peptide. FE-1 is enriched 5-6 fold in the faeces compared with pancreatic juices and can be used as an indicator of pancreatic exocrine function. Test Usage. Additionally, people who are carriers of one mutated copy of the CFTR gene, the gene typically responsible for cystic fibrosis, may have pancreatic insufficiency and experience the associated signs and symptoms. Lhr, J. et. Cleveland Clinics Endocrinology & Metabolism Institute is committed to providing the highest quality healthcare for patients with diabetes, endocrine and metabolic disorders, and obesity.